2021–22 Egyptian Second Division

The 2021–22 Egyptian Second Division was the 42nd edition of the Egyptian Second Division, the top Egyptian semi-professional level for football clubs, since its establishment in 1977. The season started on 30 September 2021 and concluded on 4 June 2022. Fixtures for the 2021–22 season were announced on 12 September 2021.

Aswan, El Dakhleya and Haras El Hodoud won Group A, Group B and Group C respectively and secured the promotion to the 2022–23 Egyptian Premier League.

Format
The league consists of 48 teams divided into 3 groups of 16 teams each, with each group covering different parts of Egypt:
 * Group A for teams from Upper Egypt and eastern governorates.
 * Group B for teams from Greater Cairo, and central and north-eastern governorates.
 * Group C for teams from Alexandria and northern governorates.

The top team from each group earns promotion to the next season of the Egyptian Premier League, while the bottom 4 teams from each group get relegated to the Egyptian Third Division.

Teams

 * Team name followed with ↓ indicates the team was relegated from the 2020–21 Egyptian Premier League.
 * Team name followed with ↑ indicates the team was promoted from the 2020–21 Egyptian Third Division.

Group A
 * Al Aluminium
 * Aswan↓
 * Asyut Petroleum
 * Al Badari↑
 * Beni Suef
 * Dayrout
 * Faiyum
 * KIMA Aswan
 * Al Madina Al Monawara↑
 * Mallawi↑
 * Media
 * El Minya
 * MS Tamya↑
 * Qena
 * Sohag
 * Telephonat Beni Suef

Group B
 * Belbeis↑
 * Benha↑
 * El Dakhleya
 * El Entag El Harby↓
 * Al Merreikh
 * Al Nasr
 * Petrojet
 * Port Fouad↑
 * Porto Suez
 * El Qanah
 * El Sekka El Hadid
 * Suez
 * Telecom Egypt↑
 * Tersana
 * Wadi Degla↓
 * ZED

Group C
 * Abou Qir Fertilizers
 * Ala'ab Damanhour
 * Baladeyet El Mahalla
 * Dikernis
 * Al Hammam
 * Haras El Hodoud
 * Kafr El Sheikh
 * El Magd↑
 * El Mansoura
 * Al Masry (Al Saloum)↑
 * Olympic Club
 * Pioneers↑
 * El Raja
 * Said El Mahalla↑
 * Sporting Alexandria
 * Al Zarka