2021–22 Empoli FC season

The 2021–22 season was the 102nd season in the existence of Empoli F.C. and the club's first season back in the top flight of Italian football. In addition to the domestic league, Empoli participated in this season's edition of the Coppa Italia.

Matches
The league fixtures were announced on 14 July 2021.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center"| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center"| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center"| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center"| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center"| Players transferred out during the season