2021–22 FC Lokomotiv Moscow season

The 2021–22 season was the 97th season in the existence of FC Lokomotiv Moscow and the club's 26th consecutive season in the top flight of Russian football. In addition to the domestic league, Lokomotiv Moscow participated in this season's editions of the Russian Cup, the Russian Super Cup and the UEFA Europa League.

Group stage
The draw for the group stage was held on 27 August 2021.