2021–22 FC Midtjylland season

The 2021–22 season was FC Midtjylland's 23rd season of existence, and their 21st consecutive season in the Danish Superliga, the top tier of football in Denmark. As a result of the club's runner-up finish in 2020–21, it competed in the 2021–22 UEFA Champions League, and subsequently in the 2021–22 UEFA Europa League and the 2021-22 UEFA Europa Conference League. The Black Wolves completed a successful 2021–22 campaign with a second-place finish in the Superliga, again qualifying for the Champions League, and also captured its second Danish Cup, after defeating OB in the final on penalties.

Appearances
Includes all competitive matches.

Goalscorers
This includes all competitive matches.

Assists
This includes all competitive matches.

Clean sheets
This includes all competitive matches.

Disciplinary record
This includes all competitive matches.