2021–22 FC Spartak Moscow season

The 2021–22 season was the 100th season in the existence of FC Spartak Moscow and the club's 30th consecutive season in the top flight of Russian football. In addition to the domestic league, Spartak Moscow participate in this season's editions of the Russian Cup and the UEFA Champions League.

Third qualifying round
The draw for the third qualifying round was held on 19 July 2021.

Group stage
The draw for the group stage was held on 27 August 2021.

Knockout stage
The draw for the round of 16 was held on 25 February 2022. RB Leipzig won on walkover after Spartak Moscow were disqualified as a result of UEFA's suspension of Russian clubs from all competitions following the Russian invasion of Ukraine.

Appearances and goals

 * colspan="14"|Players who suspended their contracts:
 * colspan="14"|Players who suspended their contracts:


 * colspan="14"|Players away from the club on loan:
 * colspan="14"|Players away from the club on loan:


 * colspan="14"|Players who left Spartak Moscow during the season:
 * colspan="14"|Players who left Spartak Moscow during the season:


 * }