2021–22 FC Viktoria Plzeň season

The 2021–22 season was the 110th season in the existence of FC Viktoria Plzeň and the club's 29th consecutive season in the top flight of Czech football. In addition to the domestic league, Viktoria Plzeň participated in this season's editions of the Czech Cup and the UEFA Europa Conference League.

First-team squad
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Second qualifying round
The draw for the second qualifying round was held on 16 June 2021.

Third qualifying round
The draw for the third qualifying round was held on 19 July 2021.

Play-off round
The draw for the play-off round was held on 2 August 2021.