2021–22 First Women's Basketball League of Serbia

The 2021–22 First Women's Basketball League of Serbia (Прва женска лига Србије 2021–22.) will be the 16th season of the First Women's Basketball League of Serbia, the highest professional basketball league in Serbia. Also, it will be the 78th national championship played by Serbian clubs inclusive of the nation's previous incarnations as Yugoslavia, Serbia and Montenegro.

Crvena zvezda mts is the defending champion.

Teams
A total of 12 teams participated in the 2021–22 First Women's Basketball League of Serbia as confirmed by the Basketball Federation of Serbia on 30 June 2021.

Distribution
The following is the access list for this season.

Promotion and relegation

 * Teams promoted from the Second League
 * Proleter 023
 * Vršac


 * Teams relegated to the Second League
 * Novosadska ŽKA
 * Spartak

Playoffs
The four highest-placed teams from the Regular season will qualify for the Playoffs.

Semifinals

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Finals

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