2021–22 Genoa CFC season

The 2021–22 season was the 129th season in the existence of Genoa C.F.C. and the club's 15th consecutive season in the top flight of Italian football. In addition to the domestic league, Genoa participated in this season's edition of the Coppa Italia.

Matches
The league fixtures were announced on 14 July 2021.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season