2021–22 Ghana Premier League

The 2021–22 Ghana Premier League was the 66th season of the top professional association football league in Ghana which began on 29 October 2021 and concluded on 19 June 2022. Hearts of Oak were the defending champions.

Asante Kotoko won the league for a record-extending 25th time and the first since 2014 after a 1–1 draw against Ashanti Gold and were handed the trophy on the season's final day after a 3-0 triumph over relegated Elmina Sharks. As champions, Kotoko will participate in the qualification procedures for the following season's CAF Champions League.

Teams
Eighteen teams competed in the league; the 15 from the previous season and the 3 winners of the Division One League zones. The promoted teams were Bibiani Gold Stars and Accra Lions, who both achieved promotion for the first time. RTU returned to the league for the first time since their relegation in 2013. They replaced Ebusua Dwarfs, Liberty Professionals and Inter Allies.

Club managers and captains
The table lists club managers.

Promotion play-offs
On July 17 the GFA annound that there will be a play-off between the three second-placed clubs in the Division One Leagues.

The three 2nd placed clubs, Tamale City FC, Mysterious Ebusua Dwarfs FC and Liberty Professionals will play in a three-way League to determine the replacement for AshantiGold SC.

Hat-tricks
(H) – Home team (A) – Away team
 * Notes

Monthly awards
As of 4 May 2022