2021–22 Ghana Women's Premier League

The 2021–22 Ghana Women's Premier League (GWPL) is the top division league for women. The league was launched in 2012 and the 2021–22 is set to be its 9th season. Ampem Darkoa Ladies were crowned champions after beating Hasaacas Ladies 5–3 on penalty after 1–1 draw after extra time during the Championship final.

Season Overview
In 2021, the Executive Council of the Ghana Football Association (GFA) decided to expand the League from its current format 16 Clubs to 18 Clubs beginning from this season, meaning nine teams for the respective zones to allow for a minimum of 16 league matches in a season. The league as usual is set to be played in two zones: the Northern Zone and the Southern Zone. Winners of the northern and southern zones then meet in a championship final to declare the champions for the season. The season for 2021–2022 was set to kick off in late 2021.

Faith Ladies FC, Army Ladies FC were promoted from the southern zone Division One League and Savannah ladies and Dreamz Ladies FC were promoted from the northern zone.

Stadiums and locations
Note: Table lists in alphabetical order.

Club managers and captains
Note: Table lists in alphabetical order.

Northern Zone
 Source:  Ghana Football Association

Southern Zone
 Source:  Ghana Football Association

Monthly awards
The monthly awards were sponsored by NASCO Ghana.

Annual awards
The annual awards were given at the end of the season.