2021–22 Holy Cross Crusaders men's basketball team

The 2021–22 Holy Cross Crusaders men's basketball team represented the College of the Holy Cross in the 2021–22 NCAA Division I men's basketball season. The Crusaders, led by third-year head coach Brett Nelson, played their home games at the Hart Center in Worcester, Massachusetts as members of the Patriot League.

Previous season
In a season limited due to the ongoing COVID-19 pandemic, the Crusaders finished the 2020–21 season 5–11 in Patriot League play before suspending their season after positive COVID-19 tests within the program. They did not participate in the Patriot League tournament.

Schedule and results
!colspan=9 style=|Non-conference regular season

!colspan=9 style=|Patriot League regular season

!colspan=9 style=|Patriot League Tournament