2021–22 K.V. Oostende season

The 2021–22 season was the 118th season in the existence of K.V. Oostende and the club's 10th consecutive season in the top flight of Belgian football. In addition to the domestic league, K.V. Oostende also participated in this season's edition of the Belgian Cup.

Matches
The league fixtures were announced on 8 June 2021.