2021–22 Karlsruher SC season

The 2021–22 season was Karlsruher SC's 70th season in existence and the club's third consecutive season in the 2. Bundesliga, the second tier of German football. The club also participated in the DFB-Pokal.

Background and pre-season
Karlsruher SC finished the 2020–21 season in 6th place, 10 points below the automatic promotion places and 12 points below the promotion play-off place.