2021–22 Liga Iberdrola de Rugby

The 2021–22 Liga Iberdrola de Rugby was the 12th season of the Liga Iberdrola de Rugby, the top flight of Spanish domestic women's rugby union competition and the 6th to be sponsored by Iberdrola. The reigning champions entering the season where Complutense Cisneros who claimed their 1st league title after winning the 2020-21 final against Majadahonda.

Teams
Eight teams competed in the league – the top seven teams from the previous season and Sant Cugat who were promoted as champions of the 2020–21 Honor Division B. They replaced Les Abelles who were relegated after just one season in the top flight.

Relegation playoff
The team finishing in 7th place faces the runner-up of the Honor Division B, with the winner of this match playing in the 2022–23 Liga Iberdrola and the loser in the 2022–23 Honor Division B.