2021–22 Lille OSC season

The 2021–22 season was the 78th season in the existence of Lille OSC and the club's 22nd consecutive season in the top flight of French football. In addition to the domestic league, Lille participated in this season's editions of the Coupe de France, the Trophée des Champions, and the UEFA Champions League.

Matches
The league fixtures were announced on 25 June 2021.

Group stage
The draw for the group stage was held on 26 August 2021.

Round of 16
The draw for the round of 16 was held on 13 December 2021.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season