2021–22 MSV Duisburg season

The 2021–22 MSV Duisburg season was the 122nd season in the club's football history. In 2021–22 the club played in the 3. Liga, the third tier of German football alongside the Lower Rhine Cup.

Competitions
Times from 1 July to 30 October 2020 and from 27 March to 30 June 2021 are UTC+2, from 31 October 2020 to 26 March 2021 UTC+1.

Matches
The league fixtures were announced on 1 July 2021.

Squad statistics
† Player left during the season