2021–22 Mansfield Town F.C. season

The 2021–22 season was Mansfield Town's 125th year in their history and ninth consecutive season in League Two. Along with the league, the club also competed in the FA Cup, the EFL Cup and the EFL Trophy. The season covered the period from 1 July 2021 to 30 June 2022.

Pre-season friendlies
The Stags announced they would play friendlies against Retford United, Matlock Town, Grimsby Town, Alfreton Town, Hull City, Coventry City, Basford United and Nottingham Forest U23s as part of the club's pre-season preparations.

Matches
Mansfield Town's fixtures were announced on 24 June 2021. On 7 July, the scheduled fixtures with Newport County were reversed due to renovation works at Rodney Parade.

FA Cup
Mansfield were drawn away to Sunderland in the first round, Doncaster Rovers in the second round and home to Middlesbrough in the third round.

EFL Cup
Mansfield were drawn at home to Preston North End in the first round.