2021–22 Marshall Thundering Herd women's basketball team

The 2021–22 Marshall Thundering Herd women's basketball team represented Marshall University during the 2021–22 NCAA Division I women's basketball season. The Thundering Herd, led by fifth-year head coach Tony Kemper, played their home games at Cam Henderson Center in Huntington, West Virginia as members of the Conference USA. They finished with a record of 15–13, 10–8 in C-USA play to finish in fifth place in the East Division. They lost to Rice in the second round of the C-USA tournament.

Schedule and results
!colspan=12 style=|Non-conference regular season

!colspan=12 style=|C-USA regular season

!colspan=12 style=| C-USA Tournament


 * Source: Marshall University Athletics