2021–22 Missouri Tigers women's basketball team

The 2021–22 Missouri Tigers women's basketball team represented the University of Missouri during the 2021–22 NCAA Division I women's basketball season. The Tigers, led by twelfth-year head coach Robin Pingeton, played their home games at Mizzou Arena and competed as members of the Southeastern Conference (SEC).

Previous season
The Tigers finished the season 9–13 (5–9 SEC) to finish in tenth place in the conference. The Tigers were invited to the 2021 Women's National Invitation Tournament where they lost to Fresno State in the first round.

Schedule
!colspan=9 style=| Exhibition

!colspan=9 style=| Non-conference regular season

!colspan=9 style=| SEC regular season

!colspan=9 style=| SEC Tournament

!colspan=9 style=| WNIT