2021–22 North Alabama Lions women's basketball team

The 2021–22 North Alabama Lions women's basketball team represented University of North Alabama during the 2021–22 NCAA Division I women's basketball season. They were led by ninth-year head coach Missy Tiber. The Lions played their home games at the Flowers Hall in Florence, Alabama as members of the Atlantic Sun Conference (ASUN).

This was North Alabama's final of a four-year transition period from Division II to Division I. As a result, the Lions were not eligible for NCAA postseason play but were eligible to participate in the ASUN tournament.

Previous season
The Lions finished the 2020–21 season 7–18, 6–9 in ASUN play, to finish in sixth place in their conference. They advanced to the quarterfinals of the ASUN tournament.

Schedule
Source:

!colspan=12 style=| Non-Conference Regular Season

!colspan=12 style=| ASUN regular season

!colspan=12 style=| Atlantic Sun tournament