2021–22 Paris Saint-Germain F.C. (women) season

The 2021–22 season was the 51st season in the existence of Paris Saint-Germain Féminine and the club's 35th season in the top flight of French football. In addition to the domestic league, they participated in the Coupe de France Féminine and the UEFA Women's Champions League.

Ahead of the 2021–22 season, it was announced that Olivier Echouafni would leave the club after three seasons in charge with former Nice men's manager Didier Ollé-Nicolle replacing him as manager.

Trophée des Championnes
PSG qualified for the Trophée des Championnes by winning the 2020–21 Division 1 Féminine, but the match was cancelled due to the ongoing impacts of the COVID-19 pandemic in France.

Group stage
The group stage draw was held on 13 September 2021.

Knockout phase
The draw for the knockout phase was held on 20 December 2021.

Quarter-finals
Paris Saint-Germain won 4–3 on aggregate.

Semi-finals
Lyon won 5–3 on aggregate.