2021–22 Pyramids FC season

The 2021–22 Pyramids FC season was the club's 14th season in existence and the fifth consecutive season in the top flight of Egyptian football. In addition to the domestic league, Pyramids participated in this season's editions of the Egypt Cup, the EFA Cup and the CAF Confederation Cup.

Matches
The league fixtures were announced on 12 October 2021.

Qualifying rounds
The draw for the qualifying rounds was held on 13 August 2021.

Group stage
The draw for the group stage was held on 28 December 2021.