2021–22 Royale Union Saint-Gilloise season

The 2021–22 season was the 124th season in the existence of Royale Union Saint-Gilloise and the club's first season back in the top flight of Belgian football since the 1973. In addition to the domestic league, Royale Union Saint-Gilloise also participated in this season's edition of the Belgian Cup, where they reached the sixth round, being knocked out by KV Mechelen.

Matches
The league fixtures were announced on 8 June 2021.

Squad appearances and goals

 * Last updated on 22 May 2022

! colspan=14 style=background:#dcdcdc; text-align:center|Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center|Defenders

! colspan=14 style=background:#dcdcdc; text-align:center|Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center|Forwards

! colspan=14 style=background:#dcdcdc; text-align:center|Players who have made an appearance this season but have left the club


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