2021–22 SBV Vitesse season

The 2021–22 season was the 129th season in the existence of SBV Vitesse and the club's 32nd consecutive season in the top flight of Dutch football. In addition to the domestic league, Vitesse participated in this season's editions of the KNVB Cup and the inaugural UEFA Europa Conference League.

Matches
The league fixtures were announced on 11 June 2021.

Third qualifying round
The draw for the third qualifying round was held on 19 July 2021.

Play-off round
The draw for the play-off round was held on 2 August 2021.

Group stage
The draw for the group stage was held on 27 August 2021.

Knockout round play-offs
The draw for the knockout round play-offs was held on 13 December 2021. 

Round of 16
The draw for the round of 16 was held on 25 February 2022.