2021–22 SC Paderborn 07 season

The 2021–22 season was the 115th season in the existence of SC Paderborn 07 and the club's second consecutive season in the second division of German football. In addition to the domestic league, SC Paderborn participated in this season's edition of the DFB-Pokal.

Matches
The league fixtures were announced on 25 June 2021.