2021–22 SK Slavia Prague season

The 2021–22 season was the 130th season in the existence of SK Slavia Prague and the club's 29th consecutive season in the top flight of Czech football. Domestically, Slavia finished the season 2nd in the league and reached the quarterfinal's of the Czech Cup. In Europe, Slavia where knocked out of the Champions League at the Third qualifying round stage by Ferencváros, the Play-off round of the UEFA Europa League by Legia Warsaw and reached the quarterfinal of the UEFA Europa Conference League where they were defeated by Feyenoord.

Qualifying rounds
The draw for the third qualifying round was held on 19 July 2021.

Qualifying rounds
The draw for the play-off round was held on 2 August 2021.

Knockout phase
The draw for the knockout round play-offs was held on 13 December 2021.

The round of 16 draw was held on 25 February 2022.

The draw for the quarter-finals was held on 18 March 2022.

Appearances and goals

 * colspan="16"|Slavia Prague B Players:
 * colspan="16"|Slavia Prague B Players:


 * colspan="16"|Players away from Slavia Prague on loan:
 * colspan="16"|Players away from Slavia Prague on loan:


 * colspan="16"|Players who left Slavia Prague during the season:
 * colspan="16"|Players who left Slavia Prague during the season:


 * }

Clean sheets
Kolář & Kovář both played in Slavia's 3-0 win against Fastav Zlín on 20 April 2022