2021–22 Second Men's League of Serbia (basketball)

The 2021–22 Second Men's League of Serbia is the 16th season of the Second Basketball League of Serbia, the 2nd-tier men's professional basketball league in Serbia.

Teams
A total of 16 teams participated in the 2021–22 Second Men's League of Serbia, divided into two geographical groups with 8 clubs.

In August 2021, the Basketball Federation of Serbia confirmed a disaffiliation of Fair Play and their merge into Spartak. Spartak took the Fair Play's spot for the  2021–22 season.