2021–22 Senegal Ligue 1

The 2021—22 Ligue 1 was a season of top-flight football in Senegal.

Casa Sports won the title for the second time and first since 2012 after drawing 1–1 against Tengueth FC on the second-to-last match day. The champions also won the double, defeating l'Etoile Lusitana 3–0 in the cup final to go with their league championship.

ASEC Ndiambour were relegated on the final day of the season after losing to AS Pikine after keeping their hopes alive with a win in the penultimate matchday. Ndiambour departed Ligue 1 after a four-season stay. Mbour Petite Côte were confirmed relegated after a 2–1 defeat to CNEPS Thiès in round 24, exiting the top flight for the first time since 2012.