2021–22 Stade Rennais F.C. season

The 2021–22 season was the 120th season in the existence of Stade Rennais and the club's 28th consecutive season in the top flight of French football. In addition to the domestic league, Rennes participated in this season's editions of the Coupe de France and the UEFA Europa Conference League.

First-team squad
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Matches
The league fixtures were announced on 25 June 2021.

Play-off round
The draw for the play-off round was held on 2 August 2021.

Group stage
The draw for the group stage was held on 27 August 2021.

Round of 16
The round of 16 draw was held on 25 February 2022.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season