2021–22 UEFA Champions League group stage

The 2021–22 UEFA Champions League group stage began on 14 September 2021 and ended on 9 December 2021. A total of 32 teams competed in the group stage to decide the 16 places in the knockout phase of the 2021–22 UEFA Champions League.

Sheriff Tiraspol made their debut appearance in the group stage, becoming the first team from Moldova to play in the Champions League group stage.

Draw
The draw for the group stage was held on 26 August 2021, 18:00 CEST (19:00 TRT), in Istanbul, Turkey. The 32 teams were drawn into eight groups of four. For the draw, the teams were seeded into four pots, each of eight teams, based on the following principles: Teams from the same association, and due to political reasons, teams from Ukraine and Russia, cannot be drawn into the same group. Prior to the draw, UEFA formed pairings of teams from the same association (one pairing for associations with two or three teams, two pairings for associations with four or five teams) based on television audiences, where one team was drawn into Groups A–D and another team was drawn into Groups E–H, so that the two teams would play on different days. The following pairings were announced by UEFA after the group stage teams were confirmed:
 * Pot 1 contained the Champions League and Europa League title holders, and the champions of the top six associations based on their 2020 UEFA country coefficients.
 * Pot 2, 3, and 4 contained the remaining teams, seeded based on their 2021 UEFA club coefficients.


 * A Chelsea and Manchester City
 * B Atlético Madrid and Sevilla
 * C Inter Milan and Juventus
 * D Bayern Munich and Borussia Dortmund
 * E Lille and Paris Saint-Germain
 * F Real Madrid and Barcelona
 * G Manchester United and Liverpool
 * H Porto and Benfica
 * I Shakhtar Donetsk and Dynamo Kyiv
 * J RB Leipzig and VfL Wolfsburg
 * K Atalanta and Milan

On each matchday, one set of four groups played their matches on Tuesday, while the other set of four groups played their matches on Wednesday, with the two sets of groups alternating between each matchday. The fixtures were decided after the draw, using a computer draw not shown to public. Each team would not play more than two home matches or two away matches in a row, and would play one home match and one away match on the first and last matchdays (Regulations Article 16.02). This arrangement was different from previous seasons, where the same two teams would play at home on the first and last matchdays.

Teams
Below were the participating teams (with their 2021 UEFA club coefficients), grouped by their seeding pot. They included:
 * 26 teams which entered in this stage
 * 6 winners of the play-off round (4 from Champions Path, 2 from League Path)

Notes

Format
In each group, teams played against each other home-and-away in a round-robin format. The top two teams of each group advanced to the round of 16. The third-placed teams were transferred to the Europa League knockout round play-offs, while the fourth-placed teams were eliminated from European competitions for the season.

Tiebreakers
Teams were ranked according to points (3 points for a win, 1 point for a draw, 0 points for a loss). If two or more teams were tied on points, the following tiebreaking criteria were applied, in the order given, to determine the rankings (see Article 17 Equality of points – group stage, Regulations of the UEFA Champions League): Due to the abolition of the away goals rule, head-to-head away goals were no longer applied as a tiebreaker starting from this season. However, total away goals were still applied as a tiebreaker.
 * 1) Points in head-to-head matches among the tied teams;
 * 2) Goal difference in head-to-head matches among the tied teams;
 * 3) Goals scored in head-to-head matches among the tied teams;
 * 4) If more than two teams were tied, and after applying all head-to-head criteria above, a subset of teams were still tied, all head-to-head criteria above were reapplied exclusively to this subset of teams;
 * 5) Goal difference in all group matches;
 * 6) Goals scored in all group matches;
 * 7) Away goals scored in all group matches;
 * 8) Wins in all group matches;
 * 9) Away wins in all group matches;
 * 10) Disciplinary points (direct red card = 3 points; double yellow card = 3 points; single yellow card = 1 point);
 * 11) UEFA club coefficient.

Groups
The fixtures were announced on 27 August 2021, the day after the draw. The matches were played on 14–15 September 28–29, September 19–20, October 2–3, November 23–24, November, and 7–8 December 2021. The scheduled kick-off times were 18:45 (two matches on each day) and 21:00 (remaining six matches) CET/CEST.

Times were CET/CEST, as listed by UEFA (local times, if different, are in parentheses).