2021–22 UEFA Europa League knockout phase

The 2021–22 UEFA Europa League knockout phase began on 17 February with the knockout round play-offs and ended on 18 May 2022 with the final at the Ramón Sánchez Pizjuán Stadium in Seville, Spain, to decide the champions of the 2021–22 UEFA Europa League. A total of 24 teams competed in the knockout phase.

Times are CET/CEST, as listed by UEFA (local times, if different, are in parentheses).

Qualified teams
The knockout phase involved 24 teams: the 16 teams which qualified as winners and runners-up of each of the eight groups in the group stage, and the eight third-placed teams from the Champions League group stage.

Format
Each tie in the knockout phase, apart from the final, was played over two legs, with each team playing one leg at home. The team that scored more goals on aggregate over the two legs advanced to the next round. If the aggregate score was level, then 30 minutes of extra time was played (the away goals rule was not applied). If the score was still level at the end of extra time, the winners were decided by a penalty shoot-out. In the final, which was played as a single match, if the score was level at the end of normal time, extra time was played, followed by a penalty shoot-out if the score was still level.  The mechanism of the draws for each round was as follows:
 * In the draw for the knockout round play-offs, the eight group runners-up were seeded, and the eight Champions League group third-placed teams were unseeded. The seeded teams were drawn against the unseeded teams, with the seeded teams hosting the second leg. Teams from the same association could not be drawn against each other.
 * In the draw for the round of 16, the eight group winners were seeded, and the eight winners of the knockout round play-offs were unseeded. Again, the seeded teams were drawn against the unseeded teams, with the seeded teams hosting the second leg. Once again, teams from the same association could not be drawn against each other.
 * In the draws for the quarter-finals onwards, there were no seedings, and teams from the same association could be drawn against each other. As the draws for the quarter-finals and semi-finals were held together before the quarter-finals were played, the identity of the quarter-final winners was not known at the time of the semi-final draw. A draw was also held to determine which semi-final winner was designated as the "home" team for the final (for administrative purposes as it was played at a neutral venue).

In the knockout phase, teams from the same or nearby cities (Porto and Braga, as well as Sevilla and Real Betis) were not scheduled to play at home on the same day, due to logistics and crowd control. To avoid such scheduling conflicts, adjustments had to be made by UEFA. For the knockout round playoffs and a round of 16, since both teams were drawn to play at home in a given leg, the home match of the team that was not domestic cup champions in the qualifying season, or the team with the lower domestic ranking (if neither team were the domestic cup champions, i.e. Porto and Real Betis for this season), was moved from Thursday to Wednesday. For the quarter-finals and semi-finals, if the two teams were drawn to play at home for the same leg, the order of legs of the tie involving the team with the lowest priority was reversed from the original draw.

Schedule
The schedule was as follows (all draws were held at the UEFA headquarters in Nyon, Switzerland).

Bracket
 

Knockout round play-offs
 The draw for the knockout round play-offs was held on 13 December 2021, 13:00 CET. 

Summary
 The first legs were played on 17 February, and the second legs were played on 24 February 2022.


 * }

Matches
Sevilla won 3–2 on aggregate.

Atalanta won 5–1 on aggregate.

RB Leipzig won 5–3 on aggregate.

Barcelona won 5–3 on aggregate.

Real Betis won 3–2 on aggregate.

Rangers won 6–4 on aggregate.

''2–2 on aggregate. Braga won 3–2 on penalties.''

Porto won 4–3 on aggregate.

Round of 16
 The draw for the round of 16 was held on 25 February 2022, 12:00 CET. 

Summary
 The first legs were played on 9 and 10 March, and the second legs were played on 17 March 2022.

Notes 
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Matches
Rangers won 4–2 on aggregate.

Braga won 3–1 on aggregate.

Lyon won 2–1 on aggregate.

Atalanta won 4–2 on aggregate.

West Ham United won 2–1 on aggregate.

Barcelona won 2–1 on aggregate.

RB Leipzig won on walkover.

Eintracht Frankfurt won 3–2 on aggregate.

Quarter-finals
 The draw for the quarter-finals was held on 18 March 2022, 13:30 CET. 

Summary
 The first legs were played on 7 April, and the second legs were played on 14 April 2022.


 * }

Matches
RB Leipzig won 3–1 on aggregate.

Eintracht Frankfurt won 4–3 on aggregate.

West Ham United won 4–1 on aggregate.

Rangers won 3–2 on aggregate.

Semi-finals
<section begin=SF /> The draw for the semi-finals was held on 18 March 2022, 13:30 CET, after the quarter-final draw. <section end=SF />

Summary
<section begin=SF /> The first legs were played on 28 April, and the second legs were played on 5 May 2022.


 * }<section end=SF />

Matches
Rangers won 3–2 on aggregate.

Eintracht Frankfurt won 3–1 on aggregate.

Final
<section begin=F />

The final was played on 18 May 2022 at the Ramón Sánchez Pizjuán Stadium in Seville. A draw was held on 18 March 2022, after the quarter-final and semi-final draws, to determine the "home" team for administrative purposes. <section end=F />