2021–22 US Sassuolo Calcio season

The 2021–22 season was the 102nd season in the existence of U.S. Sassuolo Calcio and the club's ninth consecutive season in the top flight of Italian football. In addition to the domestic league, Sassuolo participated in this season's edition of the Coppa Italia.

Matches
The league fixtures were announced on 14 July 2021.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season