2021–22 UTSA Roadrunners women's basketball team

The 2021–22 UTSA Roadrunners women's basketball team represents the University of Texas at San Antonio during the 2021–22 NCAA Division I women's basketball season. The team is led by first-year head coach Karen Aston, and plays their home games at the Convocation Center in San Antonio, Texas as a member of Conference USA.

Schedule and results
!colspan=12 style=|Non-conference regular season

!colspan=12 style=|CUSA regular season

!colspan=12 style=| CUSA Tournament