2021–22 Ukrainian Second League

The 2021–22 Ukrainian Second League was the 31st season since its establishment.

The competition was terminated at the PFL Council meeting on 6 May 2022 due to the 2022 Russian invasion of Ukraine.

Summary
On June 1, 2021, the PFL Central Council adopted decision that new season competitions in the PFL Second League would start on July 25, 2021, just as competitions in all professional leagues in Ukraine. The competition format and league composition corresponds to the PFL program "Strategy of Development" that was adopted back in 2016.

As the previous season the top 2 teams from each group get promoted to the First League. There also is expected to be a play-off game.

Promoted teams
Twelve teams have been promoted from the 2020–21 Ukrainian Football Amateur League:
 * Karpaty Lviv – 4th place of Group 1 (debut, last season original Karpaty Lviv withdrew)
 * MFA Mukachevo – 8th place of Group 1 (debut, another club from Mukachevo, Karpaty, last competed in 1996–97)
 * Viktoriya Mykolaivka – 1st place of Group 2 (debut)
 * LNZ Cherkasy – 2nd place of Group 2 (debut)
 * Livyi Bereh Kyiv – 6th place of Group 2 (debut)
 * AFSC Kyiv – 9th place of Group 2 (debut)
 * Lyubomyr Stavyshche – 10th place of Group 2 (debut)
 * Vovchansk – 2nd place of Group 3 (debut)
 * Sumy – 3rd place of Group 3 (debut, a phoenix club based on LS Group Sumy Raion with another FC Sumy last competed at this level in 2011–12)
 * Skoruk Tomakivka – 4th place of Group 3 (debut)
 * SC Poltava – 5th place of Group 3 (debut, another FC Poltava last competed at this level in 2011–12)
 * Trostianets – 6th place of Group 3 (debut)

Relegated teams
Two teams have been relegated from the 2020–21 Ukrainian First League:
 * MFC Mykolaiv – 4th place (the club decision to relegate)
 * Krystal Kherson – 16th place (returning after a season)

Withdrawn and merged teams

 * Obolon-2 Bucha – withdrawn before the season
 * Volyn-2 Lutsk – withdrawn before the season
 * MFC Mykolaiv-2 – Reserve club withdraw due to parent club relegated
 * FC Karpaty Lviv, officially liquidated, the 2020–21 playing and coaching staff joined FC Karpaty Halych

Location map
The following map displays the location of teams. Group A teams marked in red. Group B teams marked in green.

Results
Notes:

Post-season play-offs
Following the league season (double round-robin tournament), winners of both group are expected to meet to contest the 2021–22 Second League championship title. In addition, the third placed teams in each group expected to contest a single berth for promotion play-off with the 12th place team of the 2021–22 First League.