2021–22 Villanova Wildcats women's basketball team

The 2021–22 Villanova Wildcats women's basketball team represented Villanova University in the 2021–22 NCAA Division I women's basketball season. The Wildcats, led by 2nd-year head coach Denise Dillon, play their home games at the Finneran Pavilion and are members of the Big East Conference.

Schedule
!colspan=9 style=| Exhibition

!colspan=9 style=| Regular season

!colspan=9 style=| Big East Women's Tournament

!colspan=9 style=| NCAA Women's Tournament