2021–22 Xavier Musketeers women's basketball team

The 2021–22 Xavier Musketeers women's basketball team represents Xavier University during the 2021–22 NCAA Division I women's basketball season. The Musketeers, led by third-year head coach Melanie Moore, play their games at the Cintas Center and are members of the Big East Conference.

Schedule
!colspan=9 style=| Regular season

!colspan=9 style=|Big East tournament