2021–22 Zamalek SC season

The 2021–22 Zamalek SC season was the club's 111th season in existence and the 63rd consecutive season in the top flight of Egyptian football. In addition to the domestic league, Zamalek participated in this season's editions of the Egypt Cup, the Egyptian Super Cup the EFA Cup and the CAF Champions League.

Matches
The league fixtures were announced on 12 October 2021.

Qualifying rounds
The draw for the qualifying rounds was held on 13 August 2021.