2021 Aberto da República – Women's singles

This was the first edition of the tournament.

Panna Udvardy won the title, defeating Elina Avanesyan in the final, 0–6, 6–4, 6–3.

Seeds
• # 🇭🇺 Panna Udvardy (champion)

• # Verónica Cepede Royg (semifinals)

• # 🇧🇷 Laura Pigossi (withdrew)

• # 🇷🇴 Gabriela Lee (semifinals)

• # 🇧🇷 Carolina Alves (quarterfinals)

• # 🇷🇺 Elina Avanesyan (final)

• # 🇦🇷 María Lourdes Carlé (second round)

• # 🇨🇳 You Xiaodi (quarterfinals)