2021 Abierto Zapopan – Singles

Veronika Kudermetova was the defending champion from 2019, when the tournament was last held as a WTA 125K series event, but she chose to compete in Dubai instead.

Sara Sorribes Tormo won her first WTA Tour singles title, defeating Eugenie Bouchard in the final, 6–2, 7–5.

Seeds
• # 🇦🇷 Nadia Podoroska (second round)

• # 🇨🇿 Marie Bouzková (semifinals)

• # 🇷🇺 Anna Blinkova (first round)

• # 🇪🇸 Sara Sorribes Tormo (champion)

• # 🇯🇵 Nao Hibino (first round)

• # 🇲🇪 Danka Kovinić (second round)

• # 🇨🇦 Leylah Annie Fernandez (second round)

• # Kaja Juvan (second round)

Seeds
• # 🇺🇸 Lauren Davis (qualified)

• # 🇮🇹 Sara Errani (first round)

• # 🇪🇬 Mayar Sherif (first round)

• # 🇮🇹 Elisabetta Cocciaretto (qualified)

• # 🇦🇺 Astra Sharma (qualified)

• # 🇧🇾 Olga Govortsova (qualifying competition)

• # 🇸🇰 Kristína Kučová (first round)

• # 🇬🇧 Harriet Dart (qualifying competition, lucky loser)

• # 🇺🇸 Caroline Dolehide (qualified)

• # 🇺🇸 Usue Maitane Arconada (qualifying competition)

• # Leonie Küng (qualified)

• # 🇺🇸 Sachia Vickery (first round)

Qualifiers
• # 🇺🇸 Lauren Davis

• # Leonie Küng

• # 🇲🇽 Giuliana Olmos

• # 🇮🇹 Elisabetta Cocciaretto

• # 🇦🇺 Astra Sharma

• # 🇺🇸 Caroline Dolehide

Lucky loser

 * 1) 🇬🇧 Harriet Dart