2021 Abu Dhabi Women's Tennis Open – Singles

This was a new tournament in 2021.

Aryna Sabalenka won the title, defeating first-time finalist Veronika Kudermetova in the final, 6–2, 6–2. This was Sabalenka's third consecutive title, and her victory against Kudermetova in the final was her 15th consecutive victory, with both streaks dating back to Ostrava in 2020.

Seeds
🇺🇸 Sofia Kenin (quarterfinals) 🇺🇦 Elina Svitolina (quarterfinals) 🇨🇿 Karolína Plíšková (second round) 🇧🇾 Aryna Sabalenka (champion) 🇪🇸 Garbiñe Muguruza (third round) 🇰🇿 Elena Rybakina (quarterfinals) 🇧🇪 Elise Mertens (withdrew) 🇨🇿 Markéta Vondroušová (first round) Maria Sakkari (semifinals) 🇪🇪 Anett Kontaveit (first round) 🇺🇸 Jennifer Brady (first round) 🇨🇿 Karolína Muchová (second round, withdrew) 🇰🇿 Yulia Putintseva (third round) 🇺🇸 Amanda Anisimova (withdrew) 🇹🇳 Ons Jabeur (third round) Donna Vekić (first round) 🇷🇺 Ekaterina Alexandrova (third round)

Seeds
• # Tena Lukas (first round)

• # 🇳🇴 Ulrikke Eikeri (moved to main draw)

• # 🇬🇧 Jodie Burrage (qualifying competition, lucky loser)

• # Valentini Grammatikopoulou (qualifying competition, lucky loser)

• # 🇪🇸 Andrea Lázaro García (first round)

• # 🇭🇺 Anna Bondár (qualified)

• # Despina Papamichail (qualifying competition, lucky loser)

• # 🇺🇸 Catherine Harrison (first round)

• # 🇰🇿 Anna Danilina (first round)

• # 🇺🇦 Kateryna Bondarenko (qualified)

• # 🇫🇷 Amandine Hesse (qualified)

• # 🇷🇺 Anastasia Gasanova (qualified)

• # 🇮🇹 Jessica Pieri (qualifying competition)

• # 🇮🇹 Martina Caregaro (qualifying competition)

• # 🇷🇴 Irina Fetecău (qualifying competition)

• # 🇸🇪 Mirjam Björklund (first round)

Qualifiers
• # 🇮🇹 Lucrezia Stefanini

• # 🇷🇺 Anastasia Gasanova

• # 🇫🇷 Amandine Hesse

• # 🇺🇦 Kateryna Bondarenko

• # 🇨🇿 Lucie Hradecká

• # 🇭🇺 Anna Bondár

• # 🇨🇳 Yang Zhaoxuan

• # 🇮🇹 Bianca Turati

Lucky losers
• # 🇬🇧 Jodie Burrage

• # Valentini Grammatikopoulou

• # Despina Papamichail