2021 All-Big 12 Conference football team

The 2021 All-Big 12 Conference football team consists of American football players chosen as All-Big 12 Conference players for the 2021 Big 12 Conference football season. The conference recognizes two official All-Big 12 selectors: (1) the Big 12 conference coaches selected separate offensive and defensive units and named first- and second-team players (the "Coaches" team); and (2) a panel of sports writers and broadcasters covering the Big 12 also selected offensive and defensive units and named first- and second-team players (the "Media" team).

Quarterbacks

 * Spencer Sanders, Oklahoma State (Coaches-1)
 * Brock Purdy, Iowa State (Coaches-2; Media-1)
 * Caleb Williams, Oklahoma (Media-2)

Running backs

 * Breece Hall, Iowa State (Coaches-1; Media-1)
 * Bijan Robinson, Texas (Coaches-1; Media-1)
 * Abram Smith, Baylor (Coaches-2; Media-2)
 * Deuce Vaughn, Kansas State (Coaches-2; Media-2)

Fullbacks

 * Jeremiah Hall, Oklahoma (Coaches-1)
 * Jared Rus, Iowa State (Coaches-1)
 * Jax Dineen, Kansas State (Coaches-2)

Centers

 * Steve Avila, TCU (Coaches-2; Media-1)
 * Collin Newell, Iowa State (Coaches-2)
 * Jacob Gall, Baylor (Media-2)
 * Dawson Deaton, Texas Tech (Coaches-2)
 * Zach Frazier, West Virginia (Coaches-2)

Guards

 * Josh Sills, Oklahoma State (Coaches-1; Media-1)
 * Trevor Downing, Iowa State (Coaches-1; Media-1)
 * Marquis Hayes, Oklahoma (Coaches-2; Media-2)
 * Chris Murray, Oklahoma (Media-2)

Tackles

 * Cooper Beebe, Kansas State (Coaches-1; Media-1)
 * Connor Galvin, Baylor (Coaches-1; Media-1)
 * Derek Kerstetter, Texas (Coaches-1; Media-2)
 * Tyrese Robinson, Oklahoma (Media-2)

Tight ends

 * Charlie Kolar, Iowa State (Coaches-1; Media-1)
 * Chase Allen, Iowa State (Coaches-2)
 * Jeremiah Hall, Oklahoma (Media-2)

Receivers

 * Xavier Hutchinson, Iowa State (Coaches-1; Media-1)
 * Xavier Worthy, Texas (Coaches-1; Media-1)
 * Quentin Johnston, TCU (Coaches-1)
 * Tay Martin, Oklahoma State (Coaches-2; Media-2)
 * Tyquan Thornton, Baylor (Coaches-2; Media-2)
 * Erik Ezukanma, Texas Tech (Coaches-2)

Defensive linemen

 * Felix Anudike-Uzomah, Kansas State (Coaches-1; Media-1)
 * Will McDonald IV, Iowa State (Coaches-1; Media-1)
 * Dante Stills, West Virginia (Coaches-1; Media-1)
 * Brock Martin, Oklahoma State (Coaches-1; Media-2)
 * Eyioma Uwazurike, Iowa State (Coaches-1; Media-2)
 * Siaki Ika, Baylor (Coaches-2; Media-1)
 * Perrion Winfrey, Oklahoma (Coaches-2; Media-2)
 * Collin Oliver, Oklahoma State (Coaches-2; Media-2)
 * Kyron Johnson, Kansas (Coaches-2)
 * Ochaun Mathis, TCU (Coaches-2)
 * Isaiah Thomas, Oklahoma (Coaches-2)

Linebackers

 * Terrel Bernard, Baylor (Coaches-1; Media-1)
 * Malcolm Rodriguez, Oklahoma State (Coaches-1; Media-1)
 * Mike Rose, Iowa State (Coaches-1; Media-1)
 * Brian Asamoah, Oklahoma (Coaches-2; Media-2)
 * Nik Bonitto, Oklahoma (Coaches-2; Media-2)
 * Colin Schooler, Texas Tech (Coaches-2; Media-2)

Defensive backs

 * Jarrick Bernard-Converse, Oklahoma State (Coaches-1; Media-1)
 * Kolby Harvell-Peel, Oklahoma State (Coaches-1; Media-1)
 * Tre Tomlinson, TCU (Coaches-1; Media-1)
 * Jalen Pitre, Baylor (Coaches-1; Media-1)
 * Russ Yeast, Kansas State (Coaches-1; Media-2)
 * DaMarcus Fields, Texas Tech (Coaches-2; Media-2)
 * Christian Holmes, Oklahoma State (Coaches-2; Media-2)
 * Kenny Logan Jr., Kansas (Coaches-2; Media-2)
 * Delarrin Turner-Yell, Oklahoma (Coaches-2)
 * Isheem Young, Iowa State (Coaches-2)

Kickers

 * Jonathan Garibay, Texas Tech (Coaches-1; Media-1)
 * Gabe Brkic, Oklahoma (Coaches-2; Media-2)

Punters

 * Michael Turk, Oklahoma (Coaches-1; Media-1)
 * Cameron Dicker, Texas (Coaches-1)
 * Austin McNamara, Texas Tech (Coaches-2; Media-2)

All-purpose / Return specialists

 * Trestan Ebner, Baylor (Coaches-1; Media-1)
 * Malik Knowles, Kansas State (Coaches-1; Media-2)
 * Derius Davis, TCU (Coaches-2;
 * Brennan Pressley, Oklahoma State (Coaches-2;

Key
Bold = selected as a first-team player by both the coaches and media panel

Coaches = selected by Big 12 Conference coaches

Media = selected by a media panel