2021 Almaty Challenger II – Singles

Zizou Bergs was the defending champion but lost in the second round to Pavel Kotov.

Jesper de Jong won the title after defeating Marcelo Tomás Barrios Vera 6–1, 6–2 in the final.

Seeds
• # 🇸🇰 Andrej Martin (semifinals)

• # 🇪🇬 Mohamed Safwat (second round)

• # 🇧🇪 Kimmer Coppejans (first round)

• # 🇮🇹 Lorenzo Giustino (first round)

• # 🇰🇿 Dmitry Popko (second round)

• # 🇺🇿 Denis Istomin (first round)

• # 🇧🇷 João Menezes (second round)

• # 🇨🇦 Brayden Schnur (quarterfinals)