2021 Amstelveen Women's Open – Singles

This was the first edition of the tournament.

Quirine Lemoine won the title, defeating Yana Morderger in the final, 7–5, 6–4.

Seeds
• # 🇨🇳 Wang Xiyu (second round)

• # 🇦🇹 Barbara Haas (quarterfinals)

• # 🇧🇪 Maryna Zanevska (second round)

• # 🇦🇹 Julia Grabher (first round)

• # Tereza Mrdeža (second round)

• # 🇮🇹 Martina Di Giuseppe (first round)

• # Ekaterine Gorgodze (first round)

• # Despina Papamichail (quarterfinals)