2021 Andalucía Open – Singles

Pablo Carreño Busta defeated Jaume Munar in the final, 6–1, 2–6, 6–4 to win the inaugural Men's Singles tennis title at the 2021 Andalucía Open. Notably, this was the first tournament in ATP history to feature 4 semifinalists from the same nation.

This was the first edition of the tournament, primarily organised due to the cancellation of some tournaments in 2021, due to the COVID-19 pandemic.

Seeds
The top four seeds received a bye into the second round. • # 🇪🇸 Pablo Carreño Busta (champion)

• # 🇮🇹 Fabio Fognini (second round)

• # 🇳🇴 Casper Ruud (quarterfinals)

• # 🇪🇸 Albert Ramos Viñolas (semifinals)

• # 🇪🇸 Alejandro Davidovich Fokina (second round)

• # 🇪🇸 Feliciano López (second round)

• # 🇰🇷 Kwon Soon-woo (quarterfinals)

• # 🇦🇷 Federico Delbonis (second round)

Seeds
• # 🇷🇺 Evgeny Donskoy (qualifying competition)

• # 🇩🇪 Peter Gojowczyk (first round)

• # 🇫🇷 Antoine Hoang (first round)

• # Henri Laaksonen (qualified)

• # 🇪🇸 Bernabé Zapata Miralles (qualified)

• # 🇷🇸 Nikola Milojević (qualified)

• # 🇸🇰 Martin Kližan (first round)

• # 🇮🇹 Lorenzo Giustino (qualifying competition)

Qualifiers
• # 🇪🇸 Bernabé Zapata Miralles

• # 🇷🇸 Nikola Milojević

• # 🇪🇸 Mario Vilella Martínez

• # Henri Laaksonen