2021 Antalya Open – Singles

Lorenzo Sonego was the defending champion, but chose not to participate. Alex de Minaur defeated Alexander Bublik in the final, 2–0, after Bublik retired with an ankle injury.

Seeds
• #🇮🇹 Matteo Berrettini (quarterfinals)

• #🇧🇪 David Goffin (semifinals)

• #🇮🇹 Fabio Fognini (second round)

• #🇦🇺 Alex de Minaur (champion)

• #🇩🇪 Jan-Lennard Struff (quarterfinals)

• # Nikoloz Basilashvili (quarterfinals)

• #🇷🇸 Miomir Kecmanović (first round)

• #🇰🇿 Alexander Bublik (final, retired)

Seeds
• # 🇷🇸 Peđa Krstin (first round)

• # 🇷🇺 Pavel Kotov (qualified)

• # Blaž Kavčič (qualifying competition)

• # 🇮🇹 Andrea Pellegrino (qualifying competition)

• # 🇩🇪 Matthias Bachinger (qualified)

• # 🇪🇸 Roberto Ortega Olmedo (first round)

• # 🇸🇰 Lukáš Klein (first round)

• # 🇧🇬 Dimitar Kuzmanov (qualified)

• # 🇮🇳 Sasikumar Mukund (first round)

• # 🇦🇹 Lucas Miedler (qualifying competition)

• # 🇨🇿 Michael Vrbenský (qualified)

• # 🇸🇰 Alex Molčan (qualified)

Qualifiers
• # 🇨🇿 Michael Vrbenský

• # 🇷🇺 Pavel Kotov

• # 🇸🇰 Alex Molčan

• # 🇧🇬 Dimitar Kuzmanov

• # 🇩🇪 Matthias Bachinger

• # 🇧🇬 Adrian Andreev