2021 Aspria Tennis Cup – Singles

Hugo Dellien was the defending champion but chose not to defend his title.

Gian Marco Moroni won the title after defeating Federico Coria 6–3, 6–2 in the final.

Seeds
• # 🇦🇷 Federico Coria (final)

• # Holger Rune (semifinals)

• # 🇺🇸 Ulises Blanch (second round)

• # 🇦🇷 Facundo Mena (first round, retired)

• # Gastão Elias (quarterfinals)

• # 🇫🇷 Tristan Lamasine (second round)

• # 🇷🇺 Teymuraz Gabashvili (first round)

• # 🇮🇹 Gian Marco Moroni (champion)