2021 Australian Open – Wheelchair women's singles

Diede de Groot defeated the defending champion Yui Kamiji in the final, 6–3, 6–7(4–7), 7–6(10–4) to win the women's singles wheelchair tennis title at the 2021 Australian Open. It was the first step in an eventual Super Slam for de Groot.

Seeds
• # Diede de Groot (champion)

• # 🇯🇵 Yui Kamiji (final)