2021 BNP Paribas Open – Men's singles

Cameron Norrie defeated Nikoloz Basilashvili in the final, 3–6, 6–4, 6–1 to win the men's singles tennis title at the 2021 Indian Wells Masters. It was his first ATP Tour Masters 1000 title, and he became the first Briton to win the title. Basilashvili became the first Georgian to reach a Masters-level final since Alex Metreveli in 1968, and the first to do so while representing Georgia as an independent nation.

Dominic Thiem was the reigning champion from when the event was last held in 2019, but did not participate due to a long-standing wrist injury.

With no former champions participating, a new Indian Wells champion was guaranteed. For the first time, all four semifinalists at a Masters event were ranked outside of the world's top 25.

Seeds
All seeds received a bye into the second round. • 🇷🇺 Daniil Medvedev (fourth round)

• Stefanos Tsitsipas (quarterfinals)

• 🇩🇪 Alexander Zverev (quarterfinals)

• 🇷🇺 Andrey Rublev (third round)

• 🇮🇹 Matteo Berrettini (third round)

• 🇳🇴 Casper Ruud (fourth round)

• 🇨🇦 Félix Auger-Aliassime (second round)

• 🇵🇱 Hubert Hurkacz (quarterfinals)

• 🇨🇦 Denis Shapovalov (third round)

• 🇮🇹 Jannik Sinner (fourth round)

• 🇦🇷 Diego Schwartzman (quarterfinals)

• 🇪🇸 Pablo Carreño Busta (third round)

•  Cristian Garín (third round)

• 🇫🇷 Gaël Monfils (fourth round)

• 🇪🇸 Roberto Bautista Agut (third round)

• 🇺🇸 Reilly Opelka (third round)

• 🇮🇹 Lorenzo Sonego (second round)

• 🇬🇧 Daniel Evans (third round)

• 🇷🇺 Aslan Karatsev (fourth round)

• 🇺🇸 John Isner (third round, withdrew)

• 🇬🇧 Cameron Norrie (champion)

• 🇦🇺 Alex de Minaur (fourth round)

• 🇧🇬 Grigor Dimitrov (semifinals)

• 🇷🇺 Karen Khachanov (fourth round)

• 🇮🇹 Fabio Fognini (third round)

•  Lloyd Harris (third round)

• 🇷🇸 Filip Krajinović (third round)

• 🇷🇸 Dušan Lajović (second round)

•  Nikoloz Basilashvili (final)

• 🇪🇸 Carlos Alcaraz (second round)

• 🇺🇸 Taylor Fritz (semifinals)

• 🇺🇸 Sebastian Korda (second round)

Seeds
• # Botic van de Zandschulp (qualified)

• # 🇮🇹 Salvatore Caruso (qualified)

• # 🇦🇺 Alex Bolt (first round)

• # 🇺🇸 Maxime Cressy (qualified)

• # 🇰🇿 Mikhail Kukushkin (qualifying competition)

• # 🇷🇺 Evgeny Donskoy (qualifying competition)

• # 🇮🇹 Federico Gaio (first round)

• # 🇺🇸 Mitchell Krueger (first round)

• # Jason Jung (first round, retired)

• # 🇹🇷 Altuğ Çelikbilek (qualifying competition)

• # 🇪🇨 Emilio Gómez (qualified)

• # 🇺🇸 Bjorn Fratangelo (qualifying competition)

• # 🇺🇸 Ernesto Escobedo (qualified)

• # 🇹🇷 Cem İlkel (qualified)

• # João Sousa (qualified)

• # 🇦🇺 Thanasi Kokkinakis (first round)

• # Alejandro Tabilo (qualified)

• # 🇫🇷 Enzo Couacaud (qualifying competition)

• # 🇮🇳 Ramkumar Ramanathan (first round)

• # 🇺🇸 Christopher Eubanks (qualified)

• # Ernests Gulbis (first round)

• # 🇦🇷 Renzo Olivo (qualified)

• # Ivo Karlović (qualifying competition)

• # 🇦🇺 Aleksandar Vukic (qualified)

Qualifiers
• # Botic van de Zandschulp

• # 🇮🇹 Salvatore Caruso

• # 🇮🇹 Roberto Marcora

• # 🇺🇸 Maxime Cressy

• # 🇺🇸 Ernesto Escobedo

• # Alejandro Tabilo

• # 🇦🇷 Renzo Olivo

• # 🇹🇷 Cem İlkel

• # 🇺🇸 Christopher Eubanks

• # João Sousa

• # 🇪🇨 Emilio Gómez

• # 🇦🇺 Aleksandar Vukic