2021 Bad Homburg Open – Singles

Angelique Kerber defeated Kateřina Siniaková in the final, 6–3, 6–2, to win the singles tennis title at the 2021 Bad Homburg Open. It was Kerber's 13th career WTA Tour singles title, her first in three years.

This was the inaugural edition of the tournament.

Seeds
• # 🇨🇿 Petra Kvitová (semifinals)

• # 🇧🇾 Victoria Azarenka (quarterfinals, withdrew)

• # 🇺🇸 Jessica Pegula (second round)

• # 🇩🇪 Angelique Kerber (champion)

• # 🇦🇷 Nadia Podoroska (quarterfinals)

• # 🇷🇴 Sorana Cîrstea (first round)

• # 🇪🇸 Sara Sorribes Tormo (semifinals)

• # 🇩🇪 Laura Siegemund (quarterfinals)

Seeds
• # 🇧🇾 Yuliya Hatouka (qualified)

• # 🇮🇳 Riya Bhatia (qualifying competition, lucky loser)

• # 🇵🇱 Katarzyna Piter (qualified)

• # 🇩🇪 Anna Zaja (qualified)

• # 🇷🇺 Ekaterina Yashina (qualified)

• # 🇧🇪 Kimberley Zimmermann (qualifying competition)

• # 🇩🇪 Nastasja Schunk (qualifying competition)

• # 🇩🇪 Julia Middendorf (qualifying competition)

Qualifiers
• # 🇧🇾 Yuliya Hatouka

• # 🇷🇺 Ekaterina Yashina

• # 🇵🇱 Katarzyna Piter

• # 🇩🇪 Anna Zaja

Lucky loser
• # 🇮🇳 Riya Bhatia