2021 Barcelona Open Banc Sabadell – Singles

Rafael Nadal defeated Stefanos Tsitsipas in the final, 6–4, 6–7(6–8), 7–5 to win the singles title at the 2021 Barcelona Open. Nadal saved a championship point en route to his record-extending 12th Barcelona Open title and 61st ATP Tour singles title on clay. It became the second tournament at which Nadal had earned 12 or more victories, after the French Open. At three hours and 38 minutes, the final match was at the time the longest best-of-three-sets tour-level final since the ATP began tracking statistics in 1991, until the 2023 Cincinnati Masters final. Tsitsipas, who had also lost to Nadal in his first career ATP singles final at this tournament in 2018, was in contention to win his first ATP 500 tournament title on his seventh attempt.

Dominic Thiem was the reigning champion from when the tournament was last held in 2019, but he did not return to compete.

Seeds
All seeds receive a bye into the second round. • 🇪🇸 Rafael Nadal (champion)

• Stefanos Tsitsipas (final)

• 🇷🇺 Andrey Rublev (quarterfinals)

• 🇦🇷 Diego Schwartzman (quarterfinals)

• 🇪🇸 Roberto Bautista Agut (third round)

• 🇪🇸 Pablo Carreño Busta (semifinals)

• 🇨🇦 Denis Shapovalov (third round)

• 🇧🇪 David Goffin (third round, retired)

• 🇮🇹 Fabio Fognini (second round, defaulted)

• 🇨🇦 Félix Auger-Aliassime (quarterfinals)

• 🇮🇹 Jannik Sinner (semifinals)

• 🇷🇺 Karen Khachanov (second round)

• Cristian Garín (second round)

• 🇦🇺 Alex de Minaur (third round)

• 🇳🇴 Casper Ruud (withdrew)

• 🇬🇧 Dan Evans (second round)

• 🇫🇷 Adrian Mannarino (second round)

Seeds
• # 🇺🇸 Tennys Sandgren (first round)

• # 🇸🇪 Mikael Ymer (first round)

• # 🇪🇸 Pedro Martínez (withdrew due to illness)

• # 🇰🇿 Mikhail Kukushkin (first round)

• # 🇦🇹 Dennis Novak (first round)

• # 🇧🇾 Ilya Ivashka (qualified)

• # 🇩🇪 Peter Gojowczyk (qualifying competition)

• # 🇫🇷 Antoine Hoang (first round)

• # 🇮🇳 Sumit Nagal (qualified)

• # 🇮🇹 Federico Gaio (qualifying competition, lucky loser)

• # 🇦🇹 Jurij Rodionov (first round)

• # Henri Laaksonen (first round)

Qualifiers
• # 🇪🇸 Bernabé Zapata Miralles

• # 🇩🇰 Holger Rune

• # 🇮🇳 Sumit Nagal

• # Tallon Griekspoor

• # 🇷🇺 Andrey Kuznetsov

• # 🇧🇾 Ilya Ivashka

Lucky loser
• # 🇮🇹 Federico Gaio